The agent Co-Amoxiclav corresponds to which two drugs?

• A. Trimethoprim and Sulfamethoxazole
• B. Amoxicillin and Clavulanic acid
• C. Trimethoprim and Sulfazine
• D. Ofloxacin and Rifampicin

Answer: (B)

Co-Amoxiclav is amoxicillin combined with clavulanic acid. Amoxicillin is a beta-lactam antibiotic that disrupts bacterial cell wall synthesis. Some bacteria produce beta-lactamase enzymes that can inactivate these antibiotics. Clavulanic acid is a beta-lactamase inhibitor—it blocks those enzymes, protecting amoxicillin and extending its activity to include beta-lactamase–producing organisms. This pairing explains why the combination is effective in infections where resistance to penicillins via beta-lactamase is a concern. The other options involve different drug pairs that are not this fixed combination, so they don’t describe Co-Amoxiclav.