If an IV dose of 1000 mg yields AUC_iv = 200 mg·h/L, what is Cl?

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Multiple Choice

If an IV dose of 1000 mg yields AUC_iv = 200 mg·h/L, what is Cl?

Explanation:
For an IV dose with linear pharmacokinetics, clearance is the ratio of the dose to the AUC after that dose. Cl = Dose / AUC_iv. Plugging in the values: Cl = 1000 mg / 200 mg·h/L = 5 L/h. The units cancel as mg cancels out, leaving L/h. This result shows that a given dose produces an AUC of 200 mg·h/L, corresponding to a clearance of 5 L/h.

For an IV dose with linear pharmacokinetics, clearance is the ratio of the dose to the AUC after that dose. Cl = Dose / AUC_iv.

Plugging in the values: Cl = 1000 mg / 200 mg·h/L = 5 L/h. The units cancel as mg cancels out, leaving L/h.

This result shows that a given dose produces an AUC of 200 mg·h/L, corresponding to a clearance of 5 L/h.

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