Co-Trimazine is the combination of which two drugs?

• A. Trimethoprim + Sulfamethoxazole
• B. Amoxicillin + Clavulanic acid
• C. Ofloxacin + Rifampicin
• D. Trimethoprim + Sulfadiazine

Answer: (D)

Co-Trimazine combines two drugs that work together to block bacterial folate synthesis more effectively than either alone. Sulfamethoxazole inhibits dihydropteroate synthase, and trimethoprim inhibits dihydrofolate reductase; together they shut down the folate pathway in two steps, producing a strong bactericidal effect.

The standard fixed-dose combination used clinically is trimethoprim with sulfamethoxazole, not sulfadiazine. Sulfadiazine is a different sulfonamide and is not paired with trimethoprim in this combination.

So, the correct pairing for Co-Trimazine is trimethoprim and sulfamethoxazole.