A drug is given as a continuous IV infusion aiming for Css,inf. If Cl = 6 L/h and target Css = 4 mg/L, what is the required infusion rate?

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Multiple Choice

A drug is given as a continuous IV infusion aiming for Css,inf. If Cl = 6 L/h and target Css = 4 mg/L, what is the required infusion rate?

Explanation:
At steady state with a continuous IV infusion, the amount entering per hour equals the amount leaving per hour. The rate of elimination at steady state is Cl × Css, so the infusion rate must match that: Rate_in = Cl × Css. Plugging in the values: 6 L/h × 4 mg/L = 24 mg/h. So the required infusion rate is 24 mg per hour (which is 0.4 mg/min). This assumes linear pharmacokinetics where clearance is constant.

At steady state with a continuous IV infusion, the amount entering per hour equals the amount leaving per hour. The rate of elimination at steady state is Cl × Css, so the infusion rate must match that: Rate_in = Cl × Css.

Plugging in the values: 6 L/h × 4 mg/L = 24 mg/h. So the required infusion rate is 24 mg per hour (which is 0.4 mg/min). This assumes linear pharmacokinetics where clearance is constant.

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